Infectious Disease

The Interview: Dr. Kuppermann and Dr. Burstein On The Study That Will Change Everything (for Febrile Infants)

PEM Clinicians: If you find this kind of breakdown useful, HipPEMcrates delivers concise, evidence-based PEM insights and expert conversations – without oversimplifying the science. Go to HipPEMcrates.com/subscribe to get new posts directly to your inbox. Hot Off the Press! Last week, JAMA published a new study titled “Prediction of Bacteremia and Bacterial Meningitis Among Febrile […]

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TEASER…The Study That Will Change Everything (for Febrile Infants)

Hot Off the Press! This past Monday, JAMA published a new study titled “Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger.” The study evaluated whether the PECARN Febrile Infant Prediction Rule (you know the one – negative urine, serum procalcitonin ≤0.5 ng/mL, and ANC ≤4000/mm3) can be applied to

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Clinical Scenario: The Floppy Infant with Constipation

The Case A 3-month-old breastfed male is brought to the ED with: On exam: You pause. The baby’s floppy. He’s not febrile. He’s not actively seizing. But something is clearly wrong. Diagnosis: Infant Botulism This is classic: a floppy, constipated infant with descending paralysis. Pathophysiology: Key Clinical Clues PEM Pearl: A floppy, afebrile infant with

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2 High-Stakes Misses in the Pediatric ED

Pediatric emergency departments often see children with a wide range of conditions, from mild illnesses to life-threatening diseases. It’s helpful when serious conditions like volvulus present with clear and obvious symptoms, such as bilious emesis in a newborn. However, the challenge—and anxiety—arises when an urgent or emergent condition mimics a more benign presentation. Two such

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